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Figure 3 shows the potential place of oral semaglutide as per international treatment recommendations.[30,32,33] Oral semaglutide is approved for use in all stages of CKD irrespective of eGFR without any dose adjustment as per the US prescribing information

It has been estimated that 12% of the US population has had exposure to a GLP-1RA and 6% are currently using one 11

Alloxan hepatic metabolism may have been responsible for the increase in ALT/AST levels in diabetic animals, since the structural similarity with the glucose molecule allows its absorption by the cell through the GLUT2 transporter 38 , occasioning possible damage to cells which express this carrier
