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Effects of dieting-related messages on psychological and weight control variables

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These comparisons point out that tirzepatide offers benefits from targeting two hormones

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White fat (especially visceral fat) can slow down your metabolism over time

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Depression and mood alterations warrant particular attention, especially in individuals with a history of mood disorders

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Keywords: diabetes, obesity, G protein coupled receptor, glucagon-like peptide, GLP-1, weight loss, peptide, non-alcoholic hepatosteatosis, Alzheimers disease Graphical abstract Highlights Circulating levels of semaglutide overlap with oral versus subcutaneous administration Pharmacokinetics of semaglutide predict reductions in HbA 1c and body weight Route of semaglutide administration does not influence pharmacodynamic outcomes Body weight influences circulating levels of semaglutide in people with diabetes Determinants of GLP-1 action include the gut-brain axis, interindividual differences in GLP-1 receptor expression, differential drug access to key tissues, and circulating levels of bioactive peptide

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Acute treatment effects were analyzed using unpaired Students t-tests

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