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The August 2023 announcement of topline results was followed in November 2023 by a presentation of detailed results7, which revealed a statistically significant reduction in non-fatal myocardial infarction of 28% and smaller reductions in cardiovascular death and non-fatal stroke which were not statistically significant over the length of the trial (up to five years)

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Importantly, large-scale randomized trials, meta-analyses, and observational studies suggest that GLP-1RAs do not significantly increase AKI risk and may even confer renal benefits in high-risk populations

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