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The SURMOUNT-1 trial for weight management showed similar patterns, with gastrointestinal events being the most common adverse reactions and a leading cause of treatment discontinuation
Cramping responds quickly to electrolyte supplementation, particularly magnesium and potassium
Concomitant use with other GLP-1 receptor agonists or incretin-based therapies is not recommended, as this combination has not been studied
Month 6+ Weight loss continues but typically at a slower pace
In some people, the gut doesn't make enough natural GLP-1, or the brain isn't sensitive to it
