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The trial randomised participants to subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg and 12 mg or placebo, administered once weekly for a total of 48 weeks
The 0.8kg average regain between plateau and week 48 compares favorably to the rapid rebound typically seen without medication support
When to seek medical attention Most injection-related issues are minor and self-resolving
These investigational therapies may expand future treatment options by improving effectiveness, convenience, and long-term weight management outcomes
People with poorly controlled type 2 diabetes often experience fatigue due to fluctuating blood glucose levels
