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A survey by benefits consultant Mercer found 49% of large employers covered GLP-1 medications in 2025, up from 41% in 2023

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doi: 10.1016/j.ebiom.2022.104296

This apparent contradiction is mechanistically reconciled through -arrestin-2s dual molecular functions: classical desensitization via termination of receptor-stimulated G protein coupling (operative at all concentrations), and scaffolding function where receptor-arrestin-2 complexes act as signaling nodes modulating intracellular pathways (prominent at higher concentrations)