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Chuck Svendsen, chief medical officer at Astride Health and former bariatric surgeon, says he's a "huge fan" of GLP-1 medications

This encouraged scientists to begin investigating whether targeting the central nervous system could provide an effective strategy for weight loss (Capozzi, DiMarchi, Tschpp)

However, patients taking multiple antihypertensive medications should have their blood pressure monitored regularly, as excessive lowering could potentially cause symptomatic hypotension, particularly in elderly patients or those with autonomic dysfunction

pancreas or gallbladder problems

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Pioglitazone has been associated with an increased risk of bladder cancer, although absolute risk remains low