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Aim for an additional liter beyond your normal 2 to 3 liters daily

In these trials, dosing was deliberately conservative at the outset in order to balance efficacy with tolerability

However, biases and residual confounding inherent to EHR-based research could not be eliminated

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-blockers have been shown to reduce mortality through various mechanisms, including the blockade of adrenergic receptors and reductions in heart rate, which can profoundly affect cellular metabolism and energy utilization (Tomiyama and Yamashina, 2014)