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"I think it's important if you have a patient who has really uncontrolled heartburn, or constipation, GI issues, that you explore those and handle those health issues before you start a GLP-1," said Dr

Semaglutide supports enhanced weight loss by staying in the body for a longer period than the natural GLP-1 hormone

However, recent studies have shown that semaglutide medications like Ozempic may increase the risk of non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can cause sudden and permanent vision loss

Most guidelines suggest stopping Ozempic at least two months before a planned pregnancy

71 A retrospective analysis found that GMIs were most common in the first months after initiating SGLT2 inhibitors and are more common in women and those with prior GMIs

Additionally, rapid reduction in CO could also lead to vigorous contraction of the LV stimulating mechanoreceptors (leading to further reflex bradycardia) and reduction in NO production, leading to less vasodilation