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Finally, when we expressed the M1 and M3 mutants, which showed a reduced LC3 and WIPI2 binding, respectively, WIPI2 puncta were restored by M1 expression (Figure 7G), while LC3 puncta were not rescued by any of the mutants (Figure 7F)

Surgery : In some cases, surgical treatment may be recommended if a person is not responding to medication
Here's what the evidence says

Looking at weekly averages reveals the true trajectory

A balanced diet that includes protein, fats, and carbohydrates is critical for weight loss and overall health

Noticeable improvement in recovery within the first week