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7 In particular, weight loss induced by GLP-1 RAs has been associated with significant improvement in debilitating headaches, especially in conditions such as idiopathic intracranial hypertension (IIH) and migraine, both of which are known to be exacerbated by obesity and its associated systemic inflammation

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It has a neuroendocrine pathway independent of the GLP-1 receptors, working by stimulating melanocortin-4 receptors (MC4R) to reduce hunger and increase basal metabolic rate

P values lower than 0.05 were considered significant

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