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Proper refrigeration, handling protocols, and understanding individual metabolic factors can significantly impact treatment success and safety outcomes

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Monotherapy showed higher AE rates

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95% CI, 0.680.84

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A stratified next-generation trial could test whether semaglutide works in the right patients even at the same 14 mg dose that failed in an unselected population

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Semaglutide is a glucagon-like peptide-1 receptor agonist which has been shown to reduce body weight and improve health status in patients with obesity related heart failure with preserved ejection fraction in the STEP-HFpEF Program [1]

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