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This guide compares GLP-1 medications and bariatric surgery side by side, including weight loss results, side effects, recovery, costs, nutritional considerations, and long-term maintenance

It is not currently approved for type 2 diabetes in the US, though Lilly has stated its intention to file for that indication during 2026

[DOI] [PMC free article] [PubMed] [Google Scholar] 98.Mishra R, Raj R, Elshimy G, Zapata I, Kannan L, Majety P, et al

Clinical study suggesting that DPP-4 inhibition blocks distal, rather than proximal, sodium reabsorption after prolonged therapy in patients with T2DM, potentially as a result of decreased inactivation of SDF1 rather than a mechanism involving GLP-1

This metabolic adaptationa drop in resting metabolic rateis a normal physiological response, not medication failure

b Composite treatment consists of treatment of DR with anti-VEGF agents, panretinal laser photocoagulation, or vitrectomy