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Despite not being a primary aim of the study, by collecting participant characteristics we saw clinically significant improvements in physical health (weight and HbA1c), of similar magnitude to that seen in trials of GLP-1 receptor agonists in obesity [35] and T2D and overweight [36, 37]

If you have been at a dose that previously produced noticeable appetite suppression and that effect suddenly disappears, potency loss is a possible explanation

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