glp-1 agonist prediabetes GLP1 Receptor Agonists—Effects beyond Obesity and Diabetes Episode 481: Prediabetes & Diabetes

32 An observational study found that GLP-1 RAs users experienced reduced risks of mortality (6.8% vs

MACE, Major adverse cardiovascular events

They work through different biological mechanisms and are not interchangeable

[35,36] Berberine also seems to have favorable effects on blood cholesterol and triglycerides, which is to be expected since AMPK promotes fat uptake as much as glucose uptake

These medications mimic or enhance the action of natural incretins and are prescribed for type 2 diabetes management and, in some cases, weight management

Complementary in vitro studies revealed that liraglutide exerted a dose-dependent inhibitory effect on the secretion of pro-inflammatory mediators, including interleukin 6 (IL-6), prostaglandin E2 (PGE2), and nitric oxide (NO), and suppressed the expression of inflammatory genes in chondrocytes and macrophages [45]