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Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are a well-established class of glucose-lowering drugs

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Compared to baseline, DIO mice assumed phylogenetically similar gut bacterial compositional changes following liraglutide and GUB09-145 treatment, characterized by discrete shifts in low-abundant species and related bacterial metabolic pathways

At present, GLP-1RAs have become highly effective treatments for managing type 2 diabetes mellitus and obesity

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As doctors learn why GLP-1s don't work for about 50% of people, they are also learning more about the complex drivers of obesity