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In a Phase 3 trial, orforglipron demonstrated a reduction in HbA1c levels by up to 1.6% and an average weight loss of 16 pounds over 40 weeks

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effective contraception should be discussed with women of childbearing potential The medication should be discontinued at least 1 month before a planned pregnancy [2] Tirzepatide can reduce the exposure to oral contraceptives

When combined with intensive behavioral therapy (STEP 3), results were even stronger participants achieved approximately 16% weight loss at 68 weeks with the added benefit of structured dietary and exercise guidance (Wadden et al., 2021)

Recent retrospective cohort analysis of 15,330 patients with PC and diabetes showed that use of DPP-4 inhibitors only ( n = 441) (HR 0.77