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In Rett syndrome, the loss of functional MECP2 disrupts the normal silencing of genes by H3K9 methylation (Tillotson and Bird, 2020)

It is important first to rule out normal fluctuations in weight that occur from water retention, hormone changes, waste elimination, and sleep disruption, he explains
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The specific mechanism of how GLP-1RAs can cross the blood-brain barrier and reach the hypothalamus has been a matter of debate
