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This, however, cannot be uncoupled from the weight loss produced by tirzepatide based on the current study design

Lillys drug uses a new active ingredient, called orforglipron

Characterisation of glucose-dependent insulinotropic polypeptide receptor antagonists in rodent pancreatic beta cells and mice

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Thus, intestinal proglucagon is cleaved into distinct fractions that are different from those derived in the pancreas

This is not a GLP-1 receptor agonist