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It is not recommended in patients with severe gastrointestinal disease, including severe gastroparesis

28 The weight loss effects of treatments were most pronounced within the initial 20 weeks, with most patients experiencing 55% to 90% of the total anticipated weight loss

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The researchers found that turning off GLP-1 in the brain didnt affect the normal daily intake of food, but instead was important in several specific situations: prolonged fasting, large feedings, and stress-induced appetite loss.[ref] Controlling binging, regulating satiety: Essentially, the neurons activated by GLP-1 help to limit binging after a fast they keep you from massively overeating after not eating for a while

Mounjaro lowers blood glucose in a glucose-dependent manner, meaning it prompts insulin production when blood sugar levels are higher