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Apart from the pancreas, GLP-1R is also widely distributed in various tissues of the body including the lungs, kidneys, central nervous system, cardiovascular system, gastrointestinal tract, and skin and vagus nerves ( Glucagon like peptide-1 receptor agonists (GLP-1RAs) are emerging glucose control drugs, which are widely used in the treatment of T2MD in recent years

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all patients were treated with metformin (13/13), and one was additionally treated with insulin (Tresiba/degludec insulin)

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