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They also slow gastric emptying, prolonging the sensation of fullness after meals, and act on appetite centres in the brain to reduce hunger and food intake
GLP-1s have been used to treat Type 2 Diabetes since 2005

Dipeptidyl peptidase IV inhibitors and the incretin system in type 2 diabetes mellitus

Once-Weekly Semaglutide for Weight Management: A Clinical Review
Moreover, in the SPP/PS1 transgenic AD mouse model, therapy with DA5-CH improved the memory function of AD animals and decreased the levels of amyloid senile plaques and phosphorylated tau protein in the hippocampus [57]