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Mounjaro's sales dip: How cheap generics are redrawing India's GLP-1 market The arrival of cheaper semaglutide alternatives signals that the Indian obesity drug market has moved from a launch-led boom into something more structurally competitive Eli Lilly's Mounjaro posted its first monthly sales drop in India in Marcha Rs 20-crore decline, from roughly Rs 135 crore in February to Rs 114 crorejust days after a clutch of Indian generics entered the country's booming GLP-1 market

Past saturation, extra agonist molecules produce diminishing returns while the dose-dependent side effects keep climbing

They are caused by the herpes simplex virus type 1 (HSV-1) , though herpes simplex virus type 2 (HSV-2) can occasionally be responsible

Patients with active liver disease, severe renal impairment, or unstable cardiovascular conditions require extra caution

However, it is noteworthy that genetic inhibition of IGF-1 and IGF-1R signaling has also shown beneficial effects in AD models [219]

Some preliminary research suggests berberine may influence incretin secretion indirectly, but this does not make it a GLP-1 agonist in the pharmacological sense