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doi: 10.1007/s10067-023-06612-w

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Ongoing Research and Future Possibilities While semaglutide shows promise for managing colitis, more research is needed to fully understand how it can be best used for this condition

What Does the Medical Literature Say

and in children and adolescents [Grade C, Level 3] [42] Long-acting daily basal insulin analogues may be used in place of NPH insulin to: Improve A1C [Grade B, Level 2] [44] in all ages Minimize the risk of hypoglycemia [Grade B, Level 1A] [43,44] in all ages Minimize the risk of severe hypoglycemia in adults [Grade B, Level 1A] [27,45,46] and severe or nocturnal hypoglycemia in children and adolescents [Grade B, Level 1A] [27,46] Reduce the risk of DKA [Grade B, Level 2] [47] in children Improve TIR and glycemic variability [Grade B, Level 2] [47] in children Ultralong-acting basal insulin analogues may be used in place of long-acting insulin analogues to: Minimize the risk of hypoglycemia: Reduce the risk of hyperglycemia with ketosis in children and adolescents [Grade B, Level 2] [55] Reduce glycemic variability in adults prone to severe nocturnal hypoglycemia [Grade C, Level 3] [51,52] and in toddlers and preschool aged children [Grade B, Level 2] [47] Ultralong-acting daily basal insulin analogues may be preferred over weekly basal insulin to: AID AID should be used in all individuals with type 1 diabetes to improve A1C, TIR, hypoglycemia, fear of hypoglycemia, unawareness of hypoglycemia, diabetes distress, and quality of life without increasing the risk of DKA [Grade A, Level 1A] [59,60,66,121]