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Lipolysis GLP-1 receptor agonists release fatty acids from stored fat deposits to boost the effectiveness of metabolic systems, which is similar to the effects of intermediate fasting

This occurs through directly stimulating POMC/CART neurons and indirectly inhibiting neuropeptide Y (NPY) and agouti-related peptide (AgRP) neurons, which can lead to reduced energy intake [3]

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If symptoms remain severe after 12 weeks, your provider may adjust your dose, switch you to a different formulation (oral versus injection), or recommend the Precision Peptide Genetic Test to identify whether specific genetic variants predict your individual tolerance profile

This genetic insight, available after your first month of treatment, allows your provider to optimize your semaglutide dose and identify whether a different compound like tirzepatide might suit your biology better