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Notably, dietary restriction alone was insufficient to reverse visceral adipocyte hypertrophy in females, while males showed partial responsiveness

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Susan Mollan, a consultant neuro-ophthalmologist at the University Hospitals Birmingham in the United Kingdom, wrote in an email that past trials in people with diabetes have shown that when a patients blood sugar control is tightened, they may have a paradoxical worsening of their diabetic retinopathy (temporarily), so its plausible that the GLP-1 drugs, which also help control blood sugar, could have a paradoxical biological effect. Mollan wrote an editorial that was published alongside the new study

Pancreatitis typically presents with: Severe, persistent abdominal pain (often radiating to the back) Nausea and vomiting Fever (in many cases) Rapid pulse Abdominal tenderness If pancreatitis is suspected, Saxenda must be discontinued immediately and not restarted if pancreatitis is confirmed