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Weight loss may plateau, blood glucose targets remain out of reach, or side effects limit long-term use

How Genetics Can Play a Role Genes that influence appetite, satiety, and how efficiently you store or burn energy can tilt the playing field
Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products
Pancreatic -cells respond to changes in blood glucose levels through insulin secretion, whereas intestinal L-cells respond to various nutrients, such as amino acids, fatty acids, glucose, and bile acids, through incretin secretion under physiological conditions 35

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Comparing mechanism, onset, clinical efficacy, and tolerability helps clarify which class aligns with individual patient factors and treatment goals
