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Other studies using rodents or primates with immunofluorescent reporter GLP-1Rs verify the expression of GLP-1Rs by pyramidal (glutamergic), GABAergic and catecholaminergic neurons in feeding, energy homeostasis, fear, stress, motivation/reward, learning plus memory as well as Alzheimers disease (AD) and Parkinsons Disease (PD)-associated key brain areas, such as the hippocampus, hypothalamus, cortex, striatum, amygdala, SNpc, or ventral tegmental area (VTA) (Cork et al., 2015

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Ann Intern Med 2012;156:2736 [DOI] [PubMed] [Google Scholar] 13.Shah BR, Hux JE, Laupacis A, Zinman B, van Walraven C

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Disease severity plays a crucial rolepatients with more advanced type 2 diabetes or higher degrees of obesity typically require longer treatment durations and may need indefinite therapy

[2] The theoretical basis for transdermal berberine delivery rests on principles of percutaneous absorption, but the practical effectiveness depends on numerous factors including patch formulation, skin characteristics, and importantly, berberine's physicochemical properties