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Semaglutide was associated with a significantly lower risk of opioid overdose during a 1-year follow-up compared with other antidiabetic medications, including other GLP-1RAs, with HRs ranging from 0.32 (95% CI, 0.12-0.89) to 0.58 (95% CI, 0.38-0.87) (Figure)

By suppressing hunger signals and promoting feelings of fullness, Semaglutide enables individuals to consume fewer calories, thereby aiding in weight management

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You might consider asking your provider about a maintenance dose if: Youre at or near your goal weight and feel good about your results Youve reached a weight range your provider considers healthier for your body Your weight has stayed relatively stable for several weeks Youve built sustainable eating, movement, and lifestyle habits that support long-term stability Maintenance dosing is often part of a planned transition rather than a sudden change