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The mean body mass index (BMI) in the GLP-1 group was 35.6 kg/m 2 with a SD of 6.9

However, the relatively rapid onset and short duration of action of meglitinides suits their use as prandial glucose-lowering agents (22,42)
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Allison Rhodes, M.D., a dual board-certified physician in internal medicine and obesity medicine with The Ohio State University Wexner Medical Centers Comprehensive Weight Management Program

Even though the groups were matched at the start, researchers could not measure things that changed over the year, such as weight loss, migraine severity, medication use patterns or lifestyle changes

This means they don't undergo the same rigorous testing as standard pharmaceuticals
