glp-1 nobel prize GLP-1-based therapy for obesity Lotte Bjerre Knudsen, 2025 Breakthrough

The SMGT-GLP-1 Nano Microneedle Patch offers a long-lasting, slow release of the medication, ensuring a stable effect over 24 hours without causing any discomfort

Discussion While GLP-1 RAs are powerful anti-obesity medications (AOMs), they do raise some serious concerns most notably, up to 40% of the profound weight loss induced by these agents can be due to loss of lean mass 3,4,5 and prior studies have shown that a significant portion of this lean mass is muscle 33,34,35

But its initial promise failed to pan out, as treatments mimicking leptin in the body didnt spur weight loss

Kilgore KP, Lee MS, Leavitt JA et al (2017) Re-evaluating the incidence of idiopathic intracranial hypertension in an era of increasing obesity

FR758 strain ( swEx520[pbec1:BEC-1:GFP + rol-6(su1006)] ) was a gift from Tibor Vellai (Department of Genetics, Etvs Lornd University, Budapest, Hungary)

Cost and access matter, too