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Before anyone considers GLP-1 therapy at any dose let me be clear about who needs to avoid these medications: Personal or family history of medullary thyroid cancer or MEN-2 syndrome contraindicated History of pancreatitis may not be safe Severe gastroparesis these drugs will worsen it Pregnancy or active conception planning not recommended These are real medications with real side effects: nausea, vomiting, constipation, gallbladder problems

Oral medication has to be taken a very specific way and that might be a hindrance for some people compared to taking weekly injections. Wisconsin Public Radio, Copyright 2026, Board of Regents of the University of Wisconsin System and Wisconsin Educational Communications Board.

Thyroid dysfunction Both hypothyroidism and hyperthyroidism cause hair loss

The drugs may harness that effect

Some struggle with nutrient deficiencies due to appetite suppression

The SmPC lists cholelithiasis (gallstones) as a common side effect