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The AUC and C max ratios with or without SNAC administration remained within the 0.81.25 range.158 DDIs with Oral Contraceptives Some GLP-1 RAs and a dual GLP-1/GIP RA altered the exposure of oral contraceptives, implying the potential for clinically significant DDIs (Table 4).55,57,148,155,157,161,163 About 25% of women between the ages of 15 and 44 use oral contraceptives, highlighting the importance of studying their potential DDIs.165,166 The C max and AUC values of ethinylestradiol and levonorgestrel were not affected by the administration of 14 mg oral or 1 mg subcutaneous semaglutide, indicating that it is not clinically relevant (Table 4).56,157 Notable changes in the C max ratios of oral contraceptives after the administration of 10 g exenatide twice daily seem to be caused by their administration 30 min after exenatide, when the delayed gastric emptying effect was at its peak

J Clin Rheumatol 20(3):125129 Reddy YNV, Lewis GD, Shah SJ, Obokata M, Abou-Ezzedine OF, Fudim M, Sun J-L, Chakraborty H, McNulty S, LeWinter MM et al (2019) Characterization of the obese phenotype of heart failure with preserved ejection fraction: a RELAX trial ancillary study