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Oxidative stress is a major contributor to renal injury and is characterized by increased superoxide production, upregulation of NADPH oxidase, and impaired cAMPPKA signaling (Greco et al

Nat Rev Dis Primers

Patients taking the 15 mg dose lost an average of roughly 21% of their body weight over 72 weeks

Although this is not considered clinically relevant in most cases, caution should be exercised when co-administering medications with narrow therapeutic windows (such as levothyroxine and warfarin) (713)

0.03) mg/L ( p = 0.01) but not by metformin/placebo, and with no significant difference between treatments

Westermark, P., Andersson, A