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Caption: The before and after process of natural and synthetic GLP-1 binding to GLP-1 receptors

They're usually injected and come with high price tags (up to $1,000/month) and a long list of potential side effects, from nausea and bloating to more serious risks like pancreatitis, bone-density loss, and even tumors

Dedicated histological reassessment studies after GLP-1 RA discontinuation in MASH patients are currently lacking, representing a major evidence gap

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Endogenous GLP-1 is rapidly cleaved primarily by DPP-4 as well as neutral endopeptidase 24.11 and eliminated by renal clearance, thus resulting in a short half-life of approximately 2 min [26]

Each study was assessed across key domains, including clarity of objectives, eligibility criteria, sample size justification, outcome measurement, blinding (if applicable), and adequacy of statistical analyses