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In some patients, menopause treatment may cause side effects, such as bleeding, bloating, breast tenderness or enlargement, headaches, mood changes, and nausea
2020;43(Suppl 1):S66-76

To capture cardiorenal outcomes in the full breadth of patients encountered in clinical practice, we may need to look beyond clinical trials to real-world evidence studies, in order to confirm that CVOT findings are consistent in more diverse populations reflective of patients in the clinic [73]

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