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Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients

Ng YH, Koay YC, Marques FZ, Kaye DM, OSullivan JF

2,3 Despite the number of therapies available, there remain challenges to accessing highly effective obesity medications and thus additional options for treatment may be beneficial in closing the treatment gap, explained the authors of the report

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Biochem Biophys Res Commun 472(1):201208 Read NW, McFarlane A, Kinsman RI, Bates TE, Blackhall NW, Farrar GB et al (1984) Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon

These include amino acid sequence substitutions, fatty acid conjugation using a linker, and fusion with albumin or the IgG fragment crystallizable (Fc) region, resulting in minimal metabolism and renal excretion