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Description
Keto does not directly enhance the pharmacological action of semaglutide, but it does amplify the weight loss outcomes through complementary mechanisms
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Accordingly, a possible mechanism of action of GLP-1 RAs to reduce appetite and energy intake may involve interaction with neurons in the hypothalamus either directly (66, 67) or via the nodose ganglion (68), rather than a secondary consequence of slowing gastric emptying
How GLP-1 affects weight loss The GLP-1 hormone affects weight management in several ways

International Journal of Molecular Sciences , 22 (12), 6623
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