new weight loss drug retatrutide The next big shift in obesity care may not be surgery — it may be a weekly shot. Retatrutide, an investigational triple-action medicine, showed 28.3% average body-weight over 80 weeks in Retatrutide for Weight Loss: TRIUMPH-1

Technology appraisal guidance TA875

It was given to 29 women who were overweight or obese in a dose of 5mg or 15mg/day and compared to placebo

Human loss-of-function variants in the serotonin 2 C receptor associated with obesity and maladaptive behavior

If youre experiencing sleep issues as a result of your antidepressant, talk to your healthcare provider about changing the time you take it to see if that can be an option

Your body's natural set point and metabolic signals reassert themselves once the medication is no longer present

There is no FDA-approved dosage of Topamax for weight reduction but you will likely start on a low dose