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Significant vomiting or diarrhoea can lead to dehydration , which may increase the risk of acute kidney injury, particularly in older adults or those taking diuretics or other nephrotoxic medicines

off-target weight-loss signal discovered in early trials

UK prescribing guidelines recommend starting at the lowest available dose and increasing slowly according to the specific schedule in each product's SmPC

Of note, none of the Fab fragments collide with the membrane if the ECD assumes either a tilted or closed conformation

Sanofi holds the largest latent IP position in the field and has no disclosed program

Some of this early change may be related to water balance shifts, especially if eating habits change quickly