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Description
It is a suboptimal response that may still be clinically meaningful
It is not a standalone solution but rather a tool that makes behavioral changes more achievable by reducing appetite and cravings
11 GLP-1R Arg 299 and Trp 306 may interact with GLP-1 His 7
SURMOUNT-1: Tirzepatide for Obesity The SURMOUNT-1 trial (NEJM, 2022) studied tirzepatide weight loss in 2,539 adults with obesity (without diabetes) over 72 weeks: STEP 1: Semaglutide for Obesity The STEP 1 trial (NEJM, 2021) studied semaglutide 2.4mg in 1,961 adults with obesity (without diabetes) over 68 weeks: Cross-Trial Summary Comparing across trials (with the caveat that indirect comparison has limitations): tirzepatide 15mg produced about 6 percentage points more weight loss than semaglutide 2.4mg over similar timeframes
Order shipped with expedited shipping from Canada usually take 8-10 business days to arrive
With a 5mg/ml vial, you need 200 units, which is literally 2ml of liquid and requires a larger syringe
