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Clinicians should emphasize that lifestyle changes, particularly dietary quality and eating patterns, remain important even when structured exercise is not feasible

Safety and Tolerability of GLP-1RAs for the Treatment of Obesity Since GLP-1RA therapy is used for the treatment of type 2 diabetes, there may be concerns about whether using an antidiabetic medication to treat obesity will increase the risk of hypoglycemia in people with obesity but without diabetes

The phase 2 obesity study included a NAFLD substudy, which sought to evaluate how the use of retatrutide in patients with obesity and NAFLD would affect the amount of fat in the liver

One last thing to think about is the possibility of adverse effects

J Cell Physiol (2010) 225(2):58592.10.1002/jcp.22243 36 TerziRDindarSTerziHDemirtasO

For patients who started on tirzepatide and are considering semaglutide, or vice versa, the switching dosage chart provides the transition framework