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[2] Your medical history : Discuss any history of kidney disease, liver problems, pancreatitis, thyroid disorders, eating disorders, depression or suicidal ideation, kidney stones, or glaucoma

Calocurb just got ethics approval to conduct its fourth human clinical trial on 150 men and women measuring a number of biomarkers, including weight loss

Some weight regain is common after stopping GLP-1 therapy because appetite hormones return to baseline, but research shows most patients maintain 5070% of their weight loss long-term if they sustain healthy habits
The first GLP-1 RA , exenatide (Byetta) was first approved by the FDA in 2009 as a twice-daily injectable, intended to be taken within an hour of morning and evening meals

An fMRI study in obese individuals also reported a normalised brain response to food cues when treated with the GLP1RA exenatide [125]

Brain dopamine and obesity
