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Calocurb just got ethics approval to conduct its fourth human clinical trial on 150 men and women measuring a number of biomarkers, including weight loss

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Some weight regain is common after stopping GLP-1 therapy because appetite hormones return to baseline, but research shows most patients maintain 5070% of their weight loss long-term if they sustain healthy habits

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The first GLP-1 RA , exenatide (Byetta) was first approved by the FDA in 2009 as a twice-daily injectable, intended to be taken within an hour of morning and evening meals

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An fMRI study in obese individuals also reported a normalised brain response to food cues when treated with the GLP1RA exenatide [125]

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Brain dopamine and obesity

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