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Description
The inflammatory response can activate the UPR through three major signaling pathways (PERK, ATF-6 and IRE1)
McLAUGHLIN: I would say that all of his story is familiar in different ways
A good example of this mechanism is the use of LPR-1 as delivery system across the BBB
Nat Rev Endocrinol 22 , 416432 (2026)
Phase 3 TRIUMPH trials ongoing
Gastrointestinal side effects are most common during this dose escalation period
