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However, extreme caloric restriction or excessive weight loss can potentially disrupt hormonal balance in both sexes, potentially leading to relative energy deficiency in sport (RED-S) or hypothalamic dysfunction

GLP-1 RAs induced an early dip in eGFR, suggesting decreased intraglomerular pressure and decreased glomerular hyperfiltration, followed by slower eGFR loss in the overall population of GFR subgroups compared with placebo [13, 20], a feature shared with all currently known nephroprotective drugs ranging from reninangiotensin blockers to mineralocorticoid receptor antagonists to SGLT2is to tolvaptan [67]

These two mechanisms are independent and additive

21,25 In addition, elevated blood levels of homocysteine and high-sensitivity C-reactive protein (hs-CRP) have consistently been found to be correlated with increased atherosclerosis risk