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Different compound classes show varying susceptibility to diminished effectiveness over time

The within-subject SD for log( C max ) for digoxin (single dose) was estimated at 0.25, and the within-subject SD for log( C max ) for metformin (steady state) was estimated at 0.18

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Similarly, mice lacking ghrelin O-acyltransferase (GOAT), the enzyme generating the active form of ghrelin, display dampened sensitivity to escalating concentrations of sodium chloride, in addition to lower licking responses for high doses of intralipid [119]