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Furthermore, the risk of hypoglycaemiaa major challenge when using insulinis reportedly lower with GLP-1RAs, given their glucose-dependent mechanism of modulating insulin release and glucagon suppression [25]

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however, the small number of subjects studied (44 in total, 20 randomized to exenatide) and the limited duration of the trial limits definitive conclusions from being drawn

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Glucose-dependent insulinotropic polypeptide promotes beta-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen-activated protein kinase

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