incretin mimetics glp 1 agonists GLP-1’s (incretin mimetics), This type of medication works by increasing the levels of hormones called ‘incretins’. These hormones help the body produce more insulin only when needed and reduce the Novel therapeutics for type 2

This is primarily because incretin mimetics cater to chronic, complex conditions like T2DM that often require specialist involvement and management

Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP): a randomised, controlled, phase 3b trial

In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination

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However, adding GIP agonism significantly enhances results, suggesting GIP contributes meaningfully to overall weight loss through metabolic effects beyond pure appetite control

DPP-4 has both enzymatic and non-enzymatic roles