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In animal studies, it was linked to reduced calorie intake, improved balance of gut bacteria, and increased fullness

While such effects can lead to noticeable weight loss, they are only prescribed for individuals who meet specific medical requirements

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Pro-inflammatory cytokines produced by adipose tissue support tumor-promoting intercellular crosstalk in the tumor microenvironment [14], thus enhancing tumor cell progression, angiogenesis, and invasion as essential requirements for metastasis [15]

A reduction in the expression levels of the AGE receptor facilitated this effect

In this study we also used GWAS summary data from the GTExPortal ( and the IEU OpenGWAS project ( and the authors thank all of the investigators who provided these data to support this study