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In most cases, these reactions are self-limited and improve with proper site rotation and injection technique

Mir Ali, a bariatric surgeon at Orange Coast Medical Center, explains: "Consuming a high amount of calories can still lead to weight gain or a plateau, even on these medications

The medications may also have an ominous side effect thats not often reported

Further research is needed to elucidate the precise mechanisms through which GLP-1R agonists exert their benefits and to establish their long-term safety and efficacy in diverse HFpEF populations

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This table compares the active ingredients, FDA-approved usage, and typical weight loss or A1C reduction of some of the most well-known GLP-1s: Semaglutide vs tirzepatide Semaglutide is the active ingredient found in the injectable medications Ozempic and Wegovy (and the oral medication Rybelsus)